MicroRNA reexpression as differentiation therapy in cancer
نویسندگان
چکیده
منابع مشابه
MicroRNA reexpression as differentiation therapy in cancer.
Since their discovery in the early 2000s, microRNAs (miRNAs) and their penchant for RNA interference have taken the scientific community by storm, working their way into virtually every corner of biological inquiry. The very nature of their action, the ability to simultaneously extinguish the expression of a multitude of genes and negate their functions, immediately suggested therapeutic promis...
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Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progresse into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression l...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci40107